Marcia Haigis

Marcia Haigis, Ph.D.

Professor of Cell Biology (HMS)

Marcia C. Haigis, Ph.D. obtained her Ph.D. in Biochemistry from the University of Wisconsin in 2002 and performed postdoctoral studies at MIT studying mitochondrial metabolism. In 2006, Dr. Haigis joined the faculty of Harvard Medical School, where she is currently a Professor in the Department of Cell Biology. Dr. Haigis is an active member of the Paul F. Glenn Center for the Biology of Aging, a member of the Ludwig Center at Harvard Medical School, and was recently selected for the National Academy of Medicine Emerging Leaders in Health and Medicine Program.

The Haigis Lab aims to: 1) identify molecular mechanisms by which mitochondria respond to cellular stress and 2) elucidate how these cellular mechanisms contribute to aging and age-related diseases, such as cancer. The Haigis lab has made key contributions to our understanding of metabolic reprogramming in cancer, including identifying nodes of metabolic vulnerability in the control of fat oxidation in leukemia and metabolic recycling of ammonia to generate amino acids important for tumor growth.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6865

Uptake of lipids from ascites drives NK cell metabolic dysfunction in ovarian cancer.
Authors: Authors: Slattery K, Yao CH, Mylod E, Scanlan J, Scott B, Crowley JP, McGowan O, McManus G, Brennan M, O'Brien K, Glennon K, Corry E, Treacy A, Argüello RJ, Gardiner CM, Haigis MC, Brennan DJ, Lynch L.
Sci Immunol
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The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation.
Authors: Authors: Nelson CS, Podestà MA, Gempler MG, Lee JM, Batty CJ, Mathenge PG, Sainju A, Chang MR, Ke H, Chandrakar P, Bechu E, Richardson S, Cavazzoni CB, Tullius SG, Abdi R, Ghebremichael M, Haigis MC, Marasco WA, Sage PT.
JCI Insight
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Integrated analysis of transcriptional and metabolic responses to mitochondrial stress.
Authors: Authors: Kelley LP, Hu SH, Boswell SA, Sorger PK, Ringel AE, Haigis MC.
Cell Rep Methods
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Transforming treatment paradigms: Focus on personalized medicine for high-grade serous ovarian cancer.
Authors: Authors: Kordowitzki P, Lange B, Elias KM, Haigis MC, Mechsner S, Braicu IE, Sehouli J.
CA Cancer J Clin
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Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling.
Authors: Authors: He B, Copps KD, Stöhr O, Liu B, Hu S, Joshi S, Haigis MC, White MF, Zhu H, Tao R.
Cell Metab
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The Diabetes Gene Tcf7l2 Organizes Gene Expression in the Liver and Regulates Amino Acid Metabolism.
Authors: Authors: Krawczyk J, O'Connor W, Vendramini P, Schell M, Biddinger KJ, Pengo G, Fougeray T, Aragam KG, Haigis M, Lamers WH, Tsai LT, Biddinger SB.
bioRxiv
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GUK1 activation is a metabolic liability in lung cancer.
Authors: Authors: Schneider JL, Kurmi K, Dai Y, Dhiman I, Joshi S, Gassaway BM, Johnson CW, Jones N, Li Z, Joschko CP, Fujino T, Paulo JA, Yoda S, Baquer G, Ruiz D, Stopka SA, Kelley L, Do A, Mino-Kenudson M, Sequist LV, Lin JJ, Agar NYR, Gygi SP, Haigis KM, Hata AN, Haigis MC.
Cell
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Widespread neuroanatomical integration and distinct electrophysiological properties of glioma-innervating neurons.
Authors: Authors: Hsieh AL, Ganesh S, Kula T, Irshad M, Ferenczi EA, Wang W, Chen YC, Hu SH, Li Z, Joshi S, Haigis MC, Sabatini BL.
Proc Natl Acad Sci U S A
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Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing.
Authors: Authors: Ogawa T, Isik M, Wu Z, Kurmi K, Meng J, Cho S, Lee G, Fernandez-Cardenas LP, Mizunuma M, Blenis J, Haigis MC, Blackwell TK.
Mol Cell
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Author Correction: Branched-chain a-ketoacids aerobically activate HIF1a signalling in vascular cells.
Authors: Authors: Xiao W, Shrimali N, Vigder N, Oldham WM, Clish CB, He H, Wong SJ, Wertheim BM, Arons E, Haigis MC, Leopold JA, Loscalzo J.
Nat Metab
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